Impact of Smoking on Platelet, Coagulation and Lipid Profile in Young Male Subjects

This study aims to investigate the effects of smoking on platelets function, coagulation and lipid profiles in young males. Sixty young males (20 Cigarette smokers, 20 Shisha smokers and 20 nonsmokers) were enrolled in this study. Blood pressure, body mass index, serum lipid profile, means platelet volume, platelet count, clusters of differentiation and coaggulability were investigated. Results: There is no significant difference between the three groups as regard platelet count, mean platelet volume, Hemoglobin concentration, White Blood Cells count and Red Blood Cells count. High density lipoprotein cholesterol levels were lower in Shisha smokers group compared with nonsmokers group. Triglyceride levels were higher in Shisha smokers group compared with nonsmokers group. Fibrinogen was significantly increased for the Cigarette smokers group and Shisha group compared to non-smokers (P<.01). However, the Prothrombin Time was not changed significantly in the smokers groups. There was a significant difference in alteration of CDs markers expression in both Cigarette and Shisha smokers. The results of the current study revealed higher triglyceride levels and lower high density lipids-cholesterol levels in Shisha smokers group and significant alteration of CDs expression in both Cigarette and Shisha smokers compared to nonsmokers healthy male subjects.